Everything you need to know about NAD+ injections
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. It plays essential roles in energy production, DNA repair, cellular signaling, and metabolic function. Think of it as a crucial helper molecule that your cells need to function optimally.
NAD+ stands for Nicotinamide Adenine Dinucleotide (the + indicates its oxidized form). It's sometimes called "NAD plus" in conversation.
Multiple factors contribute to age-related NAD+ decline:
Research shows NAD+ levels can drop 10-80% from youth to old age.
NAD+ may be appropriate for adults experiencing:
Always consult a healthcare provider to determine if NAD+ is right for your individual situation.
NAD+ injections deliver the molecule directly, while NMN and NR are precursors typically taken orally that your body converts to NAD+.
Clinical studies show NAD+ supplementation has a favorable safety profile with low incidence of side effects. A 2024 pilot study found that IV infusions of NAD+ precursors were safe with only minor temporary side effects and no serious adverse events up to 14 days post-infusion.
However, long-term safety data in healthy adults is still limited. Always use NAD+ under medical supervision from a licensed provider.
Common (generally mild):
Rare:
Most side effects are mild and resolve quickly, especially when starting with lower doses.
Serious adverse events are rare in clinical studies. Theoretical concerns include:
Avoid or use with extreme caution if you have:
Your body regulates NAD+ levels, and excess is typically metabolized. However, extremely high doses (>1,000mg daily) may overwhelm your liver's processing capacity and cause complications. Never exceed recommended dosing without medical supervision. Most protocols use 50-200mg per injection.
NAD+ has relatively few known drug interactions, but you should always inform your healthcare provider of all medications and supplements you're taking. Potential considerations include:
The evidence is mixed and still emerging:
What we know for certain:
What's less certain:
A 2023 systematic review found that while many studies show improved clinical features with NAD+ supplementation, other studies showed no measurable benefits. More research is needed.
Timeline varies by individual:
Blood NAD+ levels rise within 24 hours of injection, but subjective improvements take longer.
Most users don't feel dramatic immediate effects. NAD+ works at the cellular level—benefits accumulate over time. Some people report subtle energy improvements within days, while others take 4-6 weeks to notice changes. This is a long-term optimization strategy, not a quick fix.
NAD+ has a relatively short half-life in the body. Benefits are sustained with regular dosing (typically 1-3x weekly). If you stop injections, NAD+ levels will gradually return to baseline over weeks to months, and benefits will diminish.
Common reported benefits include:
NAD+ is NOT a miracle cure. Don't expect dramatic weight loss, complete reversal of aging, or cure of chronic diseases. Think of it as one tool in a comprehensive health optimization strategy.
Partially. Animal studies show compelling evidence that NAD+ boosting can extend lifespan and healthspan in mice, worms, and other organisms. It activates sirtuins and other longevity pathways.
However, we don't yet have long-term human studies proving NAD+ extends human lifespan. The research is promising but preliminary. Current use is based on mechanistic understanding and emerging clinical evidence.
NAD+ injections are administered subcutaneously (into fatty tissue under the skin). Most people inject into the abdomen, thigh, or back of the arm. The process is similar to insulin injections—simple enough to do at home after brief instruction.
Typical protocols range from 1-3 times per week. Common schedules:
Your provider will recommend a specific protocol based on your goals and response.
Most providers recommend starting with 50-100mg per injection to assess tolerance. You can gradually increase to 100-200mg as needed. Never exceed 300mg per week without medical evaluation.
Most people describe subcutaneous NAD+ injections as virtually painless when done correctly with a small needle (29-31 gauge). You may feel a brief pinch, and occasional mild stinging during injection. Injecting slowly helps minimize discomfort.
NAD+ vials must be refrigerated at 36-46°F (2-8°C). Do not freeze. Keep away from light. Once opened, use within 28-30 days or as directed. Properly stored unopened vials typically remain stable for 6-12 months.
Yes, but you'll need to maintain refrigeration. Use an insulated cooler with ice packs. Bring your prescription documentation. NAD+ can tolerate brief temperature variations but should be kept cool as much as possible.
There's no definitive "best time," but considerations include:
Experiment to find what works best for you. Consistency matters more than specific timing.
Prices vary significantly by provider and protocol:
Weekly injection at 100mg typically costs $150-250/month.
Most insurance companies do NOT cover NAD+ injections as they're typically considered preventive/wellness rather than treatment for a specific disease. Some providers offer insurance reimbursement support, but coverage is rare. Consider this an out-of-pocket expense.
Yes. NAD+ injections are prescription-only. You'll need to consult with a licensed healthcare provider (physician, nurse practitioner, or physician assistant) who can evaluate your health and write a prescription if appropriate.
Two main options:
Telehealth is typically faster, more convenient, and more affordable.
No. Injectable NAD+ requires a prescription in the United States. Beware of websites selling injectable NAD+ without prescriptions—these are illegal and potentially dangerous (quality not guaranteed).
Oral NAD+ precursors (NMN, NR) are available over-the-counter as supplements, but injectable forms are regulated.
Depends on concentration and dosing. Common example:
Your provider will calculate supply based on your specific protocol.
Pros:
Cons:
Pros:
Cons:
Bottom line: Both can be effective. Injections may offer superior bioavailability, while oral is more convenient. Some people use both.
SubQ injections offer a middle ground: more convenient and affordable than IV, more bioavailable than oral.
NAD+ addresses a specific, well-documented age-related decline. It's not necessarily "better" than other interventions—think of it as complementary. Common longevity strategies that may work synergistically:
No single supplement is a longevity panacea. NAD+ is one tool in a comprehensive approach.
Yes, many people combine NAD+ with other peptides for synergistic effects. Common combinations (always under medical supervision):
Always discuss combinations with your provider to ensure safety and compatibility.
The best way to get personalized answers is to consult with a licensed healthcare provider who specializes in NAD+ therapy.